A basic model of hierarchical structure, expressed by simple, linear differential equations, shows that the pattern of population growth is essentially determined by conditions of redundancy in the sub-structure of individuals. There does not exist any possible combination between growth rate and accident rate that could balance population numbers and/or the level of redundancy within the population; all possible combinations either lead to extinction or to positive population growth with a decline of the fraction of individuals with redundant substructure. Declining (...) populations, however, can be held fluctuating between certain limits by periodic phases of sub-unit repair. These results are particularly pertinent to the population dynamics of diploid (polyploid) organisms. (shrink)

The theory is presented that the sexual process is a repair mechanism which maintains redundancy within the sub-structure of hierarchical, self-reproducing organisms. In order to keep the problems within mathematically tractable limits , a simple model is introduced: a wheel with 6 spokes, 3 of them vital and 3 redundant, symbolizes the individual . Random accidents destroy spokes; the wheels replicate at regular cycles and engage periodically in pairing and repair phases during which missing spokes are copy-reproduced along the intact (...) spokes of the partner wheel.The hierarchical structure of such a system is analysed and an ‘autonomous unit’ is defined: this is the unit of minimal hierarchical complexity which is capable of perpetuating autonomously all higher and all lower levels of the hierarchy; this is the central unit of selection.Four basic, physical parameters are isolated which determine the essential features of any eucaryotic life cycle: 1. The number of levels of the hierarchy ; 2. the relation between the phases of replication and repair ; 3. the duration of potential repair ; 4. the position of the sexual partners within the hierarchy .The evaluation of fitness components is considered in relation to trends of reproductive patterns in evolution. (shrink)

The paper examines a single, apparently simple argument for the existence of incompatibilities between the virtues as traits of character. This argument appeals not to empirical truths about human psychology or human nature but to the possibility of conflict between the exercise of different virtues in action. There are, for example, situations in which we can exercise the virtue of truthfulness only at the expense of not exercising the virtue of tact, as when we are asked a question to which (...) the straightforward answer will pain our questioner. The person who in these situations would give a straightforward answer possesses the virtue of truthfulness to a higher degree than the person who would respond more evasively, whereas the latter person possesses the virtue of tact to a higher degree than the former. But since the two responses are mutually exclusive, it follows that the degree to which we possess the virtue of truthfulness must, at least in some measure, correlate inversely with the degree to which we possess the virtue of tact. And similarly for many other pairs of virtues. My paper focusses on the two cardinal assumptions of this argument, viz., (i) that sometimes the exercise of one virtue can conflict with the exercise of another, and (ii) that the degree to which a person possesses a virtue correlates directly with the extent of its exercise, and defends both assumptions against a variety of objections which allege that, in different ways, they are insensitive to the complexity of the virtues. (shrink)

The argument is put forward that genetic mutations are viable then only, when the changed pattern of growth and/or metabolism is accommodated by the taxon-specific biochemistry of the organisms, i.e. by adaptive, somatic/physiological plasticity. The range of somatic plasticity under changing environmental conditions, therefore, has a certain predictive value for the kind of mutations that are likely to be viable.

The article "Picking and Choosing Among Phase I Trials", written by Jill A. Fisher, Torin Monahan and Rebecca L. Walker, was originally published Online First without Open Access. After publication in volume 16, issue 4, page 535-549 the author decided to opt for Open Choice and to make the article an Open Access publication.

Reconsideration of the logistic equation and of its expansion to the special and general Volterra competition equations in terms of mass/energy in phase-space, shows that information on the phase-spatial conditions of resource and consumers determines specific population parameters which, in turn, decide on coexistence and extinction.Thus, introduction ofInformation as a separate and independent biophysical parameter, in analogy, and in addition, to Force in Classical Physics, is necessary. This allows for quantification of informational effects on resource flows and population numbers. As (...) such, different population growth dN/dt during a competitive exclusion process, is theeffect of competition, and not itscause. (shrink)

The current major models of coexistence of species on the same resources are briefly summarized. It is then shown that analysis of supposedly competitive systems in terms of the physical four dimensions of phase-space is sufficient to understand the causes for coexistence and for competitive exclusion. Thus, the multiple dimensions of niche theory are reduced to factors which define the magnitudes of the phase-spatial system, in particular the boundaries of population spaces and of periods of activity. Excluding possible cooperative interaction (...) between consumers, it appears that coexistence of species on thesame kind of limiting resource is possible only in cases of compartmentalization either in space, or in time, of resource consumption, i.e. if each consumer species disposes of a separate resource supply. Three criteria were found to be decisive for successful compartmentalization (i.e. for coexistence): 1. the vector of the resource flow; 2. relative mobility between consumers and resource units; 3. dependence or independence of resource flow on previous consumption. The traditional terminology of niche theory and of competition theory in general proved to be inadequate for analytical treatment of problems of coexistence. (shrink)

This article empirically examines how healthy volunteers evaluate and make sense of the risks of phase I clinical drug trials. This is an ethically important topic because healthy volunteers are exposed to risk but can gain no medical benefit from their trial participation. Based on in-depth qualitative interviews with 178 healthy volunteers enrolled in various clinical trials, we found that participants focus on myriad characteristics of clinical trials when assessing risk and making enrolment decisions. These factors include the short-term and (...) long-term effects; required medical procedures; the type of trial, including its design, therapeutic area of investigation, and dosage of the drug; the amount of compensation; and trust in the research clinic. In making determinations about the study risks, participants rely on information provided during the consent process, their own and others’ experiences in clinical trials, and comparisons among studies. Our findings indicate that the informed consent process succeeds in communicating well about certain types of risk information while simultaneously creating lacunae that are problematically filled by participants through their collective experiences and assumptions about risk. We discuss the ethical implications of these findings and make recommendations for improving the consent process in healthy volunteer trials. (shrink)

Army Officers face increased moral pressure in modern warfare, where character judgement and ethical judgement are vital. This article reports the results of a study of 242 junior British Army officers using the Army Intermediate Concept Measure, comprising a series of professionally oriented moral dilemmas developed for the UK context. Results are suggestive of appropriate application of Army values to the dilemmas and of ethical reasoning aligning with Army excellence. The sample does slightly less well, however, for justification than for (...) action reasoning, and there are differences following initial training for infantry and artillery officers versus other branches of service. Dilemmas involving anti-torture methods and not covering up soldiers' failings generated best results compared to those requiring balance between compassion and mission, and negotiating personal relationships with military needs. Gender differences favouring women were less than those observed for other professional groups using similar measures. This research further develops a much-needed measure of ethical reasoning among junior Army officers, with potential for use among other ranks. This approach is advocated for other professional groups. (shrink)

In phase I clinical trials, healthy volunteers are dosed with investigational drugs and subjected to blood draws and other bodily monitoring procedures. In exchange, they are paid. Healthy volunteers are, in a very direct sense, selling access to their bodies for pharmaceutical companies and their associates to run drugs through. In his ethnographic study of socalled professional guinea pigs, Roberto Abadie writes, "Paid volunteers are well aware of the demand for an idealized, perfectly healthy volunteer. They also realize that their (...) body is a valued commodity in clinical trials research". It is perhaps surprising, then, that commodification is little discussed in the bioethics literature on phase I... (shrink)

The general inorganic nature of traditional selection theory (based on differential growth between any two systems) is pointed out, wherefrom it follows that this theory cannot provide explanations for the characteristics of organic evolution. Specific biophysical aspects enter with the complexity of macro-molecules: vital physical conditions for the perpetuation of the system, irrevocable extinction (= death) and random change leading to novelty, are the result of complexity per se. Further biophysical properties are a direct function of the pathway along which (...) random mutation in nucleic acids is converted into continuous protein — (specifically enzyme) — function, from there into organismic phenotype with fitness components which may, or may not, correspond to identifiable structural units in DNA. The general machine-like properties of enzymes, in that there is no additive relationship between structural (amino acid) composition and functional output, is discussed in more detail. The continuous growth functions of molecular concentrations, directed by enzyme turnover, determine simple laws of growth and morphogenesis in the organic hierarchy and thus of phenotype. Thus, the combined effect of DNA-structure and of environmental parameters (temperature, pressure, pH, etc.) on protein function determines ultimately the actual phenotype and hence, quality and intensity of genotypic selection. (shrink)

Exact definitions in physical and biological terms of the coefficients in Volterra's (1926, 1931) original competition equations are indispensable for the understanding of the system. In agreement with Volterra's own, but not quite sufficient specifications, it is tried in this paper to give more precise definitions of the parameters used by Volterra. This leads to some consequences; i.a. that there does not exist a principle of competitive exclusion. In order to allow for competitive exclusion — or for stabilization — the (...) Volterra equations need additional biophysical specifications and mathematical modifications. Some such modifications are proposed, for instance for aggressive interference as a function of population numbers. (shrink)

Boltzmann's gas model representing the second law of thermodynamics is based on the improbability of certain molecular distributions in space. Maxwell argued that a hypothetical ‘being’ with the faculty of seeing individual molecules could bring about such improbable distributions, thus violating the law of entropy. However, it appears that to render the molecules visible for any observer would increase the entropy more than the demon could decrease it, hence ‘Maxwell's Demon cannot operate’ . In the study presented here Maxwell's Demon (...) is interpreted in a general way as a biological observer system within systems which can upset thermodynamic probabilities provided that the relative magnitudes between observer system and observed system are appropriate.Maxwell's Demon within Boltzmann's Gas Model thus appears only as a special case of inappropriate, relative magnitude between the two systems. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:TRINITY AND CREATION IN THE THEOLOGY OF ST. THOMAS AQUINAS DAVID A. WALKER* St. Francis' Church Nottingham, England Preface IT IS BY NO MEANS fortuitous that, in the Summa Theologiae, St. Thomas's treatise concerning 'the procession of divine persons ' is succeeded immediately by the treatise concerning ' the coming forth of creatures from God '. If both the freedom of the creative act and the full consubstantiality (...) of the divine persons are to be safeguarded, then, for St. Thomas, these two types of ' procession ' must be distinguished at all costs. But although distinct, they are also related in St. Thomas's thought. It is with this fundamental relation that we shall be primarily concerned here. Therefore, the question we shall seek to explore in this study concerns the way in which St. Thomas's doctrine of the Trinity determines, informs and impinges upon his theological understanding of the created order. Creation: The ' One God, and the ' Triune God, St. Thomas's celebrated identification of essence and existence in God has important significance for St. Thomas's doctrine of creation. God, according to St. Thomas, is Creator in virtue of his nature or essence-although, of course, this fact in no way undermines the sovereign freedom and contingency of the creative act. Because it is God's nature simply to be, all being or existence outside God is ultimately traceable back to God as its source *The Rev. Dr. David A. Walker was Team Vicar of St. Francis', Clifton, Nottingham at the time of his death in 1989. This paper was given to The Thomist on his behalf by Dr. Brian Marshall of Westminster College, Oxford. 443 444 DAVID A. WALKER and first cause. Therefore, to speak of God as Creator is to speak of God's essence in operation: " Hence creation is God's action by reason of his existence, which is his very nature... " 1 The trinitarian significance of this association of creative activity primarily with the divine essence is far reaching. In so far as the divine essence is common to, and identical in, the persons of the Trinity, St. Thomas can maintain that "creative action is not peculiar to any one Person, but is common to the whole Trinity." 2 Creation, therefore, is an act in which the triune God acts as the one God; in which a trinitarian unity of operation corresponds to a trinitarian unity of being. Consequently, the creative act primarily "has to do with the unity of nature, but not with the distinction of persons." 3 However, as we shall subsequently show, this is not St. Thomas's final word on the matter. In the light of this, it is possible to discern in the theology of St. Thomas a fairly clear distinction between truths pertaining to the unity of the divine essence and truths pertaining to the trinity of divine persons. This, indeed, is the basis for the distinction between the ' one God ' (de Deo uno) and the ' triune God' (de Deo trin:o) which operates in his thought. Indeed, this distinction is evident even in the structural arrangement of the Summa Theologiae itself. This distinction is paralleled and determined by the distinction between divine truths accessible to reason and truths accessible to man exclusively through revelation and faith, i.e., between 'natural' and 'revealed' theology. These two distinctions, furthermore, are paralleled by, and culminate in, a third distinction, namely that between nature and grace. But although there is a definite parallel between these three distinctions, it is only an approximate one and must not be construed as if it were an exact correspondence, i.e., as if the truths 1 la, Q.45, a.6. All quotations from the Summa are from Summa Theologiae, Latin text and English translation, Blackfriars edition, gen. ed. Thomas Gilby, 61 vols. (London: Eyre and Spottiswoode, 1964-81). 2 Ibid. s la, Q.32, a.1. THEOLOGY OF ST. THOMAS AQUINAS 445 pertaining to the one God were exhaustively co-extensive with the spheres of reason and nature, or those relating to the triune God with faith and grace. The fact that reason and nature do not exhaust the realm of truth concerning the one God the... (shrink)

A simple model, illustrating the transition from a population of free swimming, solitary cells to one consisting of small colonies serves as a basis to discuss the evolution of the cooperative group. The transition is the result of a mutation of the dynamics of cell division, delayed cell separation leads to colonies of four cells. With this mutation cooperative features appear, such as synchronised cell divisions within colonies and coordinated flagellar function which enables the colony to swim in definite directions. (...) The selective advantages under given, environmental conditions are defined and the periods necessary for complete allelic replacement in small populations are calculated for asexual and sexual reproduction. The assumption of a steady-state population during allelic substitution is critically considered, particularly under conditions of competition. It is shown that density-dependent population control must operate in the process of selection. Sexual reproduction slows down the rate of selection even though all cells dre haploid. This phenomenon can be explained in general terms of `organizational dominance', where individual units coordinate the function of their neighbours which may be of a different allelotype.Cooperativity is pointed out as an a priori systemic feature which resides in the sub-units of systems, group formation and coordination appears thus as an almost inevitable event. A particular type of system described as ‘closed cycle of positive fitness interaction’ is discussed in more detail. It has the remarkable feature that its members cannot compete with each other; selection takes place between whole cycles .Gonium has a wide spectrum of `somatic plasticity' which enables it to assume various colonial configurations depending on physiological and environmental conditions. This feature can be explained as the result of dynamic flexibilities on the macro-molecular level. The particular relationship between the vast, molecular complexity and the relative simple dynamics of the cell cycle must lead eventually to the genetic fixation of an environmentally induced phenotype. (shrink)

Moral thinking and communication are critical competencies for confronting social dilemmas in a challenging world. We examined these moral competencies in 70 college students and graduates from Taiwan, the United Kingdom, and the United States. Participants were assessed through semi-structured written interviews, Facebook group discussions, and a questionnaire. In this paper, we describe the similarities and differences across cultural groupings in (1) the social issues of greatest importance to the participants; (2) the factors influencing their approaches to thinking about social (...) issues and communicating with others; and (3) the characteristics of their moral functioning in terms of moral awareness, moral judgment, moral discourse, and moral decision-making. (shrink)

Analysis of the biophysical conditions for a correct application of the Volterra Competition Equations with resource-independent coefficients reveals the following:The traditional, mathematical formalism with the two equations representing two straight lines at the condition of zero growth applies.

In my professional role as anatomy administrator and bequeathal secretary at a large surgical training centre, I am the first point of contact both for people wishing to donate their body, and for newly bereaved relatives telling us that their registered loved-one has died. I am involved in every stage of the process from that first phone call, through to eventual funeral service, cremation of the body and return of the ashes to the family. I am also a registered body (...) donor myself, as I strongly believe in the value of cadaveric training having seen it first hand. When prospective donors and relatives find out that I am also a registered body donor they find this to be very reassuring to know that having ‘behind the scenes’ access has not put me off, and is a good endorsement for the process, …. (shrink)

This essay equates Penrose's (1989) Emperor with the scientist engaging in mental (Schrödinger's cat) or real experiments.The simultaneous presence of apparently contradictory phase-spatial symmetry conditions on the various hierarchical levels of biological systems are seen as the result of genetic and neurophysiological information that interferes with the physico-chemical vectors between the structural components of the system, the experimenter being an integral part of this informational causality. Equations pertaining to the lowest structural levels of matter, therefore, may not be extendable over (...) higher levels of biological organization, including human science and technology, which are seen as part and parcel of biology. This situation calls for a formal theoretical biophysics which concentrates on macroscopic processes where life and, above all,Homo sapiens, is involved. (shrink)

Evidence for instances of astrophysical ‘fine tuning’ (or ‘coincidences’) is thought by some to lend support to the design argument (i.e. the argument that our universe has been designed by some deity). We assess some of the relevant empirical and conceptual issues. We argue that astrophysical fine tuning calls for some explanation, but this explanation need not appeal to the design argument. A clear and strict separation of the issue of anthropic fine tuning on one hand and any form of (...) Eddingtonian numerology and teleology on the other, may help clarify arguably the most significant issue in the philosophy of cosmology. (shrink)

A commonly used experimental procedure for the study of granulocyte kinetics involves the labelling and subsequent tracing of granulocyte DNA. Following the introduction of a label into the system, observations are made periodically on the concentration of label in the DNA of granulocytes taken from the circulating blood. A mathematical model for the expected value of this concentration has been derived, studied, and related to experimental observations from studies using P32 as a label. Insofar as the derivation of the model (...) accurately incorporates the relevant aspects of granulocyte kinetics, the model will be useful in the interpretation of the experimental observations in terms of these kinetics.Among other things, study of the model indicates that the assumption of “flash” labelling made with respect to some labels is quite crucial and needs to be examined critically. It has also been necessary to make adjustments to allow for the observed emergence of labelled cells from the marrow soon after label introduction. In addition, despite a high degree of confounding of parameter effects it has been possible to suggest bounds on some of the parameters of the model for some species. The bounds will be refined as the model is improved and more data become available. Study and development of the model continues with particular interest in generalizations to include the diseased state chronic granulocytic leukemia. (shrink)

The dynamics of populations of self-replicating, hierarchically structured individuals, exposedto accidents which destroy their sub-units, is analyzed mathematically, specifically with regardto the roles of redundancy and sexual repair. The following points emerge from this analysis:0 A population of individuals with redundant sub-structure has no intrinsic steady-statepoint; it tends to either zero or infinity depending on a critical accident rate α c . Increased redundancy renders populations less accident prone initially, but populationdecline is steeper if a is greater than a fixed (...) value α d . Periodic, sexual repair at system-specific intervals prevents continuous decline and stabilizesthe population insofar as it will now oscillate between two fixed population levels. The stabilizing sexual interval increases with increased complexity provided this is accom-panied by appropriate levels of redundancy. The model closely simulates the dynamics of heterosis effects. Repair fitness is a population fitness: the chance of an individual being repaired is a functionof the statistical make-up of the population as a whole at that particular period. Populationsliving at α > α c either engage in sexual repair at the appropriate time or they die out. The mathematical properties of the model illustrate mechanisms which possibly played arole in the evolution of a mortal soma in relation to sexual reproduction. (shrink)

Knowledge of eukaryotic life cycles and associated genome dynamics stems largely from research on animals, plants, and a small number of “model” (i.e., easily cultivable) lineages. This skewed sampling results in an underappreciation of the variability among the many microeukaryotic lineages, which represent the bulk of eukaryotic biodiversity. The range of complex nuclear transformations that exists within lineages of microbial eukaryotes challenges the textbook understanding of genome and nuclear cycles. Here, we look in‐depth at Foraminifera, an ancient (∼600 million‐year‐old) lineage (...) widely studied as proxies in paleoceanography and environmental biomonitoring. We demonstrate that Foraminifera challenge the “rules” of life cycles developed largely from studies of plants and animals. To this end, we synthesize data on foraminiferal life cycles, focusing on extensive endoreplication within individuals (i.e., single cells), the unusual nuclear process calledZerfall, and the separation of germline and somatic function into distinct nuclei (i.e., heterokaryosis). These processes highlight complexities within lineages and expand our understanding of the dynamics of eukaryotic genomes. (shrink)

Evidence for instances of astrophysical 'fine tuning' (or 'coincidences') is thought by some to lend support to the design argument (i.e. the argument that our universe has been designed by some deity). We assess some of the relevant empirical and conceptual issues. We argue that astrophysical fine tuning calls for some explanation, but this explanation need not appeal to the design argument. A clear and strict separation of the issue of anthropic fine tuning on one hand and any form of (...) Eddingtonian numerology and teleology on the other, may help clarify arguably the most significant issue in the philosophy of cosmology. (shrink)

I hope to show that each of 1, 2, and 3 are plausible, yet we can derive 4: 1. It is epistemically permissible to believe that our preferred views in multi-proposition disputes are true, or at least more likely true than not. 2. If it is epistemically permissible to believe that our preferred views in multi-proposition disputes are true, or at least more likely true than not, then it is epistemically permissible for us to believe that we are über epistemic (...) superiors to our disagreeing colleagues in multi-proposition disputes. 3. It is not epistemically permissible to believe that we are über epistemic superiors to our disagreeing colleagues in multi-proposition disputes. 4. At least one of 1, 2, or 3, is false. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Rhetorical Investigations: Studies in Ordinary Language CriticismJeffrey WalkerRhetorical Investigations: Studies in Ordinary Language Criticism. Walter Jost. Charlottesville: University of Virginia Press, 2004. Pp. xiii + 346. $55.00, hardcover.As the sixth-century BCE poet Theognis once wrote, "Hearken to me, child, and discipline your wits; I'll tell / a tale not unpersuasive nor uncharming to your heart; / but set your mind to gather what I say; there's no necessity (...) / to do what's not according to your will" (Theognidea 1235–38; my translation). While this poem ostensibly is a pederastic proposition, it is also and more fundamentally (as I have argued elsewhere) a poem about poetry as a rhetorical transaction. Poetry is the poet's act of heart-charming persuasion or seduction; the duty of the audience, the object of the poet's seduction, is to "discipline your wits," that is, to exercise hermeneutic and critical judgment on the way to understanding fully and being persuaded or unpersuaded to think or do as the poet asks (for seduction is not compulsion). Finally, and as Theognis's poetry elsewhere suggests, the audience's act of being-persuaded or unpersuaded ultimately is an enactment of, a rehearsal of, an ethical or intellectual position (stance, schêma) that is on its way (with further, repeated rehearsals) to becoming part of the audience's ethical-intellectual performative repertoire, or in other words its êthos, or what Kenneth Burke would call its identity.This richly researched, densely argued, excellent book by Walter Jost could well be understood as a modern (or postmodern) instantiation of a "Theognidean" rhetorical poetics. At one point early on, for example, Jost invokes Angus Fletcher to sum up the activities of an ordinary-language approach to poetry as "thinking the poem": "taking the poem as an occasion for thought; thinking through the poem; being aware of one's thoughts as one reads the poem; looking for some logic in the poem; allowing the poem to trigger certain lines of thought," and so forth (Fletcher, Colors of the Mind, 111–12; Jost 9–10). This is "disciplining one's wits" to "gather what the poet says" and to follow out its implications on the way to judging what Jost calls "the meaning and quality... of an experienced artifact or event or performance" (10). As Jost develops his theoretical frame, which draws most heavily from Ludwig Wittgenstein, Stanely Cavell, and Kenneth Burke—as well as a host of others in a basically pragmatist tradition—this becomes an explicitly rhetorical approach to poetry, and specifically to Robert Frost's poetry, understood as an epideictic "showing forth" of thought that invites its audience, like Theognis's addressee, to "think [End Page 178] the poem" through and to form a relationship (whether identificational or contestatory) with the system of topoi that underwrites its judgments.Rhetorical Investigations is divided into two main parts. "Book I," titled "Rhetoric: An Advanced Primer," consists of four chapters that attempt to lay out the conceptual framework for, and to philosophically justify, Jost's rhetorical-hermeneutic approach to poetry, while also setting up Robert Frost as a distinctive exemplar of a "low modernist" practice that demonstrates the central themes of ordinary-language and pragmatist philosophy, essentially by dramatizing them, and that stands as a significant (if under-appreciated) alternative to the "high modernist" mode of Ezra Pound, T. S. Eliot, and their successors. Frost, in other words (though Jost does not say this explicitly) takes the less-traveled modernist path that Kenneth Burke embarked on in Counter-Statement and pursued for the rest of his career. The key topoi for the framework laid out in these four chapters are: dialectic/dialogue as the medium for an ordinary-language philosophical practice (chap. 1); rhetorical invention as what is missing from "high modernism's" sense of epistemological crisis and anomie (chap. 2); "grammar" as the system of topoi, or commonplaces, that underwrite ordinary language-use and are instantiated by it, and that provide the grounds (what speakers "acknowledge") for deliberation and judgment in practical thought and action (chap. 3); and logic as the implicatures of ordinary-language thought that enable epideictic argument in poetry and that make it something... (shrink)

Yong Huang defends a meta-ethical moral realism (as opposed to anti-realism) that is naturalistic (as opposed to non-naturalistic) and focused on agents (as opposed to actions). In my response, I focus on two questions that Huang’s paper raises: (1) Do we have good reason to reject Aristotelian naturalism? (2) Do we have good reason to hold that the virtues are objective in the way that Zhu Xi suggests, viz., as strongly constitutive of human nature? In response to (1), I argue (...) that Aristotelian naturalism has resources for addressing Huang’s worries. In response to (2), I argue that alternative Mencian and Aristotelian views can account for the phenomena to which Zhu Xi appeals, yet without insisting that the virtues are strongly constitutive of human nature. (shrink)

Prospective developments in computer and nanotechnology suggest that there is some possibility—perhaps as early as this century—that we will have the technological means to attempt to duplicate people. For example, it has been speculated that the psychology of individuals might be emulated on a computer platform to create a personality duplicate—an “upload.” Physical duplicates might be created by advanced nanobots tasked with creating molecule-for-molecule copies of individuals. Such possibilities are discussed in the philosophical literature as (putative) cases of “fission”: one (...) person “splitting” into two. Many philosophers, perhaps most, reject the idea of fission, appealing to some form of a “no-branching” condition to rule out such possibilities. I argue, to the contrary, that there are good moral reasons to think that any account of personal identity that does not permit fission is deeply problematic, especially in connection with theorizing about criminal punishment. I discuss and reject David Lewis’ famous account of personal identity that invokes “multiple occupancy” to allow for branching. In contrast, I offer an account of personal identity that permits branching using the type/token distinction to help with such puzzling cases. (shrink)

This brief comment was a contribution to a 1995 Symposium on Feminism and Philosophy in the 1990s held at the Pacific Division Meeting of the APA in conjunction with the Society for Philosophy and Public Affairs. I suggest the usefulness of paying attention to the differences among philosophers who are women; philosophers who are feminists; philosophers who do feminist philosophy; and philosophers who want to express their feminism in their roles as philosophers. Keeping these differences in mind might help us (...) to avoid mistaken and disrespectful assumptions about both philosophers and feminist philosophy. (shrink)

I briefly reprise a few themes of my book Moral Understandings in order to address some questions about responsibility and justification. I argue for a thoroughly situated and naturalized view of moral justification that warns us not to take moral universalism too easily at face value. I also argue for the significance of reports of experience, among other kinds of empirical evidence, in testing the habitability of moral forms of life.

What does it say about you if you enjoy sexist humour? One answer to this question holds that finding sexist humour funny reveals that you have sexist beliefs, whilst another holds that it reveals nothing deeper about you at all. I argue that neither of these answers are correct, as neither can capture the feeling of unwilling complicity we often get from enjoying sexist jokes. Rather, we should navigate between these two positions by understanding the sense of humour as a (...) kind of sensibility or taste, analogous to Anne Eaton’s account of erotic taste. This allows for a fleshing out of the purely belief-centred understanding of the sense of humour, adding emotional, perceptual and motivational aspects to it. Finally, I propose that one’s sense of humour is shaped the representations one engages with, which suggests a possible avenue for habituating it in a more egalitarian direction. (shrink)

Is finding someone funny a way of treating them as an object? And if so, does that make it immoral? In this paper, I argue that seeing someone as comic involves failing to take into account their subjectivity, which makes it a form of objectification. As for the morality of this ‘comic objectification’, I argue that regarding someone with a comically objectifying attitude is wrongful when such an attitude plays a role in legitimating the oppression of members of their social (...) group. (shrink)

The present paper offers a description and analysis of a fifteenth century handbook on logic, preserved in the ms. Zwickau, Ratsschulbibliothek XXXIII.I.14, ff. 3r-223v. The volume comprises a set...

This study is the first to address the ways in which male perpetrators of intimate partner violence talk about memory in their reports of their IPV and how these are used to manage their accountability for the violence. Drawing on and developing the discursive psychological literature on talk about memory, which highlights how such talk is used to perform practical actions within interactions, a discourse analysis is conducted on interviews with six male perpetrators of recent, multiple incidents of IPV who (...) were undergoing treatment. The analysis identified the varying ways in which memory was used: first, claims of forgetting were used to avoid answering difficult and potentially incriminating questions; second, claims of clear memories were used to position partners as problematic and responsible for violence; and third, claims about simultaneously remembering and forgetting were found. The implications of these strategies for managing identity and accountability are discussed. (shrink)

What does it say about you if you enjoy sexist humour? One answer to this question holds that finding sexist humour funny reveals that you have sexist beliefs, whilst another holds that it reveals nothing deeper about you at all. I argue that neither of these answers are correct, as neither can capture the feeling of unwilling complicity we often get from enjoying sexist jokes. Rather, we should navigate between these two positions by understanding the sense of humour as a (...) kind of sensibility or taste, analogous to Anne Eaton’s account of erotic taste. This allows for a fleshing out of the purely belief-centred understanding of the sense of humour, adding emotional, perceptual and motivational aspects to it. Finally, I propose that one’s sense of humour is shaped the representations one engages with, which suggests a possible avenue for habituating it in a more egalitarian direction. (shrink)

We explored the relationship between 24 character strengths measured by the Global Assessment of Character Strengths (GACS), which was revised from the original VIA instrument, and moral functioning comprising postconventional moral reasoning, empathic traits and moral identity. Bayesian Model Averaging (BMA) was employed to explore the best models, which were more parsimonious than full regression models estimated through frequentist regression, predicting moral functioning indicators with the 24 candidate character strength predictors. Our exploration was conducted with a dataset collected from 666 (...) college students at a public university in the Southern United States. Results showed that character strengths as measured by GACS partially predicted relevant moral functioning indicators. Performance evaluation results demonstrated that the best models identified by BMA performed significantly better than the full models estimated by frequentist regression in terms of AIC, BIC, and cross-validation accuracy. We discuss theoretical and methodological implications of the findings for future studies addressing character strengths and moral functioning. (shrink)

A Principle of fundamental importance, if it is valid, for the interpretation of the Pentekontaetia is laid down by the authors of A. T.L. iii in its most rigorous terms: it is that Thucydides has set events ‘in proper order … without any deviation whatever’. The conclusion appears to the present writer to be founded ultimately on a false assumption about Thucydides' purpose in these chapters, namely that he set out to write an outline history of the period of fifty (...) years to which he refers in 118.2 and, in effect, in 97. An examination of these passages reveals that it is not the outline of a period as a period that is offered, but rather the account of a particular theme or process falling within the period: his purpose in presenting the theme there defined is to be seen from the setting of the excursus as a unit in Bk. I rather than from the statement in 97.2: the due significance of this last, and of the demarcation of a period in 118. 2, is to be seen only in this wider context. (shrink)

The two sermons edited and translated here for the first time are primary material from the years before the establishment of the Fatimid caliphate in 297/909. The authors have been identified as Abu 'Abd Allah al-Shi'i and Abu'l-'Abbas Muhammad, two brothers who were central to the success of the Ismaili da'wa in North Africa. Da'wa, a term used to describe how Muslims teach others about the beliefs and practices of their Islamic faith, therefore provide a unique view of the nature (...) and development of Islam throughout history. In this case, the primary texts shed light on the development of Islam among the Berbers of the Maghreb. The first text by Abu 'Abd Allah al-Shi'i shows how the arguments for belief in the 'imamate' of the family of the Prophet, that is, the Shi'a belief that all imams should be spiritual descendants of the Prophet Muhammad and his household, were developed and presented to bring new adherents to the cause. The Book of the Keys to Grace by his elder brother Abu'l-'Abbas, too, concerns not only the centrality of the imam in the faith but also sheds light on the hierarchy of the da'wa in this early period and its organisational sophistication. Both texts also reveal the contemporary theology propagated by the Ismaili da'wa, including for instance, the powerful analogy of Moses/Aaron and Muhammad/'Ali, the awareness of a variety of religious traditions and the use of detailed Qur'anic quotations and a wide range of hadith. As such they constitute primary source material of interest not only for Ismaili history but for this early period of Islam in general.". (shrink)

Willie James Jennings contends that the goal of whiteness is the creation and preservation of segregated space. For Jennings, whiteness, as well as upholding perceived notions of white normativity, is a way of being in the world, an imagined reality made real by our movement in physical space which destroys the identity-forming connections between communities and land. In this article I bring together Pope Francis’s reflections on the globalised economy in Laudato Si’ with the critiques of James H. Cone and (...) Jennings to demonstrate the horrific harm of whiteness on marginalised people groups and the land itself. To resist the building project of whiteness, therefore, requires attention to our relationship with land. At this point I turn more readily to the land of England, offering the beginnings of a theology of place given the substantial land holdings of the Church of England. I close by asking whether the Church of England can be trusted to use its land to dismantle whiteness given its troubling colonial history in relation to land use. (shrink)

The framework of Findlay & Walker's target article provides a first attempt to model the saccadic system at all levels. Their scheme is based on two main principles. These are “parallel processing of saccade timing and metrics” and “competitive inhibition through winner-take-all strategies.” In our opinion, however, both concepts are in their strictest sense at odds with the current knowledge of the saccadic system, and need to be refined to make the scheme more relevant.

This essay examines the questions raised about debate in _Zhuāngzǐ_ 莊子 2, the practical advice this chapter offers us for dealing with debates when they arise, and some of the questions that will predictably occur about how and why to apply that advice. On the present interpretation, _Zhuāngzǐ_ 2 argues that joining any side in a verbal conflict promotes continued conflict, and that only appreciating and working along with each speaker’s distinct point of view affords us access to what is (...) “really” or “conclusively” (_guǒ_ 果) the case. In contentious situations, the text advises that we pay close attention to speakers and their ways of life—rather than to what they are supposedly speaking about—and that we abandon any immediate goal beyond preserving our own health. Along the way, it foregrounds pleasure and comfort rather than rightness as what we are most attuned to when we listen and respond to one another’s words. (shrink)

There is widespread agreement that it would be both morally and legally wrong to treat a competent patient, or to carry out research with a competent participant, without the voluntary consent of that patient or research participant. Furthermore, in medical ethics it is generally taken that that consent must be informed. The most widely given reason for this has been that informed consent is needed to respect the patient’s or research participant’s autonomy. In this article I set out to challenge (...) this claim by considering in detail each of the three most prominent ways in which ‘autonomy’ has been conceptualized in the medical ethics literature. I will argue that whilst these accounts support the claim that consent is needed if the treatment of competent patients, or research on competent individuals, is to respect their autonomy, they do not support the claim that informed consent is needed for this purpose. (shrink)

Research in the neurosciences continues to provide evidence that sleep plays a role in the processes of learning and memory. There is less of a consensus, however, regarding the precise stages of memory development during which sleep is considered a requirement, simply favorable, or not important. This article begins with an overview of recent studies regarding sleep and learning, predominantly in the procedural memory domain, and is measured against our current understanding of the mechanisms that govern memory formation. Based on (...) these considerations, I offer a new neurocognitive framework of procedural learning, consisting first of acquisition, followed by two specific stages of consolidation, one involving a process of stabilization, the other involving enhancement, whereby delayed learning occurs. Psychophysiological evidence indicates that initial acquisition does not rely fundamentally on sleep. This also appears to be true for the stabilization phase of consolidation, with durable representations, resistant to interference, clearly developing in a successful manner during time awake (or just time, per se). In contrast, the consolidation stage, resulting in additional/enhanced learning in the absence of further rehearsal, does appear to rely on the process of sleep, with evidence for specific sleep-stage dependencies across the procedural domain. Evaluations at a molecular, cellular, and systems level currently offer several sleep specific candidates that could play a role in sleep-dependent learning. These include the upregulation of select plasticity-associated genes, increased protein synthesis, changes in neurotransmitter concentration, and specific electrical events in neuronal networks that modulate synaptic potentiation. Key Words: consolidation; enhancement; learning; memory; plasticity; sleep; stabilization. (shrink)

I argue that if we allow that Moore’s Method, which involves taking an ordinary knowledge claim to support a substantive metaphysical conclusion, can be used to support Moore’s proof an external world, then we should accept that Moore’s Method can be used to support a variety of incompatible metaphysical conclusions. I shall refer to this as “the problem of many proofs”. The problem of many proofs, I claim, stems from the theory-ladenness of perception. I shall argue further that this plethora (...) of proofs for incompatible positions leads to a darker form of skepticism, one which maintains that each of the dogmatic views is probably false. We will conclude by considering various ways a Moorean might respond to these difficulties. (shrink)

Marriage patterns of California's eighteenth and nineteenth century Spanish-Mexican families are analysed using data from genealogies and mission records. A shortage of women among the military based colonists led to an unusual marriage pattern with a large age differential between husbands and wives. The average age at marriage was 18·4 years for women and 28·4 years for men. Spatial mobility was high for both sexes, particularly for men. More husbands than wives were born in Mexico. The Monterey presidial district of (...) central California was the birthplace of a disproportionate number of husbands and the southern California districts were a source of wives. The transition between a founding population predominantly composed of Mexican immigrants and a population of native-born Californians occurred at the beginning of the nineteenth century. (shrink)

The notion of autonomy commonly employed in medical ethics literature and practices is inadequate on three fronts: it fails to properly identify nonautonomous actions and choices, it gives a false account of which features of actions and choices makes them autonomous or nonautonomous, and it provides no grounds for the moral requirement to respect autonomy. In this paper I offer a more adequate framework for how to think about autonomy, but this framework does not lend itself to the kinds of (...) practical application assumed in medical ethics. A general problem then arises: the notion of autonomy used in medical ethics is conceptually inadequate, but conceptually adequate notions of autonomy do not have the practical applications that are the central concern of medical ethics. Thus, a revision both of the view of autonomy and the practice of “respect for autonomy” are in order. (shrink)

New York City has a long history of gentrification, well demonstrated by the strategies of “revitalization” and “re-development” that have occurred in Harlem throughout the last century. Less well known is the historical, political, and social context surrounding New York’s Pier 45, also known as the Christopher Street Pier. As a historically-known gathering spot for lesbian, gay, bisexual and transgender individuals, the Christopher Street Pier gained recognition for harbouring what could be described as a queer public . However, recent processes (...) of gentrification have changed Pier 45 into the Hudson River Park, ostensibly privatizing the site. With reference to Braidotti’s nomadic subject, this paper explores the Christopher Street Pier as a representation of queer geographies. Further, it argues that the re-appropriation of the once queer public space of Pier 45 exposes a municipal agenda of surveillance in relation to sexualized and racialized identities. Through reference to the activist practices of FIERCE, a local NGO, I show how the nomadic subjectivities of queer youth open up a discussion of ethical responsibility and point toward strategic movements of resistance in the face of gentrification in New York’s West Village. (shrink)

This essay explores three issues in respect for autonomy that pose unfinished business for the concept. By this, I mean that the dialogue over them is ongoing and essentially unresolved. These are: whether we ought to respect persons or their autonomous choices; the role of relational autonomy; and whether nonhuman animals can be autonomous. In attending to this particular set of unfinished business, I highlight some critical moral work left aside by the concept of respect for autonomy as understood in (...) Beauchamp and Childress’ Principles of Biomedical Ethics. Specifically, while significant pragmatic traction is gained by the authors’ focus on autonomous choice, carving such a focus out from the broader questions of moral respect and the autonomy of the person leaves aside a number of questions that we might have thought a view about respect for autonomy in biomedicine ought to answer. These include: How should physicians respond when autonomous patients make decisions that appear nonautonomous? What is the impact of the view that autonomy is “relational” for cross-cultural differences in how autonomy is respected? If chimpanzees can be autonomous, what does that mean for how they should be treated? (shrink)